In a ‘metaphysical Connecticut’, overly-serious career-oriented doctor Lane has hired a quirky Brazilian maid. The maid, Matilde, is too depressed to clean because she longs to be a comedian. In steps Lane’s compulsively cleaning sister, Virginia. Lane’s doctor husband. Charles, leaves her for his mistress, Ana, an irresistibly charismatic, much older, Argentinian woman whom he hopes to cure of cancer. The Clean House is a comedy about loss, love, change and redemption. Can the physicians heal themselves, or is laughter the best medicine?